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腎細尿管機能에 미치는 Bradykinin의 影響

Influence of Bradykinin on the tubular function of the dog kidney

대한약리학잡지 1966년 2권 1호 p.5 ~ 12
서병철 (  ) - 전남대학교 의과대학 약리학교실

Abstract


In this study the influence of Bradykinin, a biogenic polypeptide, on the excretory function of the dog kidney was investigated, utilizing the clearance and stop-flow method. The results are summarized as follows;
1) Bradykinin administered intravenously elicited a marked antidiuresis.
2) When given into the renal artery, however, prompt increase of the urine flow, sodium excretion and free water clearance without significant change in the glomerular filtration rate ensued.
3) It was also effective during an osmotic diuresis with 10% Mannitol infusion, though the response was not so marked.
4) The stop-flow experiment showed that sodium reabsorption in the proximal tubules is inhibited by the infusion of bradykinin into the renal artery.
It was thus concluded that the diuretic effect of bradykinin given intra-arterially results from the inhibition of sodium transport in the proximal tubules.

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