잠시만 기다려 주세요. 로딩중입니다.

개의 腎臟機能에 對한 Serotomin의 作用

Action of serotonin on the renal function in the dog

대한약리학잡지 1966년 2권 1호 p.13 ~ 16
서병철 (  ) - 전남대학교 의과대학 약리학교실

Abstract


The action of serotonin (5-Hydroxytryptamine) on the excretory function of the kidney was investigated in the dog, utilizing the clearance method and the stop-flow technique.
It was shown that serotonin, 10 ㎍/kg/min, i. v., exerts a marked antidiuretic effects and elicits a marked hemodynamic changes in the kidney: a highly significant decrease of the glomerular filtration rate and a tendency of decrement in the renal plasma flow. Little change in the systemic blood pressure was noted, and the participation of the antidiuretic hormone in the antidiuretic action was ruled out by adding vasopressin to the infusion fluid. The stop-flow analysis showed that there is no evidence of altered activity in the tubules by serotonin.
It was thus concluded that serotonin elicits antidiuresis in the dog by decreasing glomerular filtration rate, which results from the constriction of Vas afferens in the glomeruli.

키워드

원문 및 링크아웃 정보
 
등재저널 정보
KAMS