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Chlorpromazine의 溶血作用에 關한 硏究

Studies on the hemolytic action of chlorpromazine

대한약리학잡지 1967년 3권 1호 p.31 ~ 41
김규태 (  ) - 부산대학교 의과대학 약리학교실

Abstract


The auther studied the hemolytic action of chlorpromazine on rabbit erythrocytes and obtained the following results:
1. Chlorpromazine caused hemolysis in vitro. The hemolytic action of chlorpromazine was milder than that of saponin(Colleman and Bell Co).
2. Cholesterol had no marked effect on chlorpromazine hemolysis.
3. Dextrose, albumin and blood plasma protected erythrocytes against chlorpromazine hemolysis.
4. The mechanism of chlorpromazine hemolysis seemed to be different from that of saponin hemolysis.
5. Chlorpromazine increased the osmotic fragility of rabbit erythrocytes.
6. The intravenous injection of chlorpromazine caused hemolysis in vivo.

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