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白鼠子宮의 Adrenotropic Receptor에 關한 追補

Supplemental studies on the adrenotropic receptors of the rat uterus

대한약리학잡지 1967년 3권 1호 p.43 ~ 49
洪起煥 (  ) - 釜山大學校 醫科大學 藥理學敎室

金奎泰 (  ) - 釜山大學校 醫科大學 藥理學敎室
李鍾四 (  ) - 釜山大學校 醫科大學 藥理學敎室

Abstract


Supplemental studies were made on the adrenotropic receptors of the rat uterus, using adrenergic activators sucth as phenylephrine, norepinephrine, epinephrine, and isoproterenol and adrenergic blocking agents such as phenoxybenzamine and inderal. The studies have revealed the following results:
1. Phenylephrine, norepinephrine, epinephrine, and isoproterenol inhibited the spontaneous motility of the isolated rat uterus in the following order:
Isoproterenol>epinephrine>norepinephrine>phenylephrine.
2. The inhibitory responses of the isolated rat uterus to phenylephrine and norepinephrine were abolished by the pretreatment with phenoxybenzamine.
3. The inhibitory responses of the isolated rat uierus to isoproterenol and epinephrine were not affected by phenoxybenzamine.
4. The motility of the isolated rat uterus pretreated with inderal was stimulated by phenylephrine, norepinephrine and epinephrine.
5. The intibitory responses of the isolated rat uterus to isoproterenol were abolished by the pretreatment with inderal.
6. The motility of the isolated rat uterus pretreated with inderal and phenoxybenzamine was not affected by phenylephrine, norepinephrine and epinephrine.
7. It is, therefore, concluded that the rat uterus has both alpha excitatory and beta inhibitory receptors, with beta inhlbitory receptors predominating.

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