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2,2´Methylene bis(3,4,6 trichlorophenoxy Acetic Acid) 및 Sodium Cholate의 간흡충 산소소비 및 살충작용

Effect of 2,2´-Methylene bis-(3,4,6-Trichlorophenoxy Acetic acid) "MTPA" and Hexachlorophene with or without Sodium Cholate on the Oxygen Consumption in Clonorchis Sinensis

대한약리학잡지 1969년 5권 1호 p.11 ~ 15
김화웅 ( Kim Hwa-Woong ) - 경북대학교 의과대학 약리학교실

김중영 ( Kim Choong-Young ) - 경북대학교 의과대학 약리학교실
윤병오 ( Yun Byung-Oh ) - 경북대학교 의과대학 약리학교실
하영호 ( Hah Young-Ho ) - 경북대학교 의과대학 약리학교실

Abstract


The inhibitory action of oxygen consumption and parasiticidal action of hexachlorophene or MTPA combined with or without sodium cholate in Clonorchis sinensis (C.S) have been observed. The results were obtained as follows.
1. In low concentration of MTPA or Hexachlorophene, they inhibited the oxygen consumption of C.S and in high concentration, inhibition of oxygen consumption and parasiticidal action was more remarkable.
2. The oxygen consumption was inhibited also in the concentration of 10^(-2) and 2×10^(-3) g/ml of sodium cholate.
3. In the presence of sodium cholate, oxygen consumption of C.S was more remarkably inhibited by MTPA or Hexachlorophene than the absence of sodium cholate. 4. From those results, it may be considered that sodium cholate combined with MTPA or Hexachlorophene produced potentiation in its action.

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