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人蔘 Saponin이 Morphine에 依한 Rat 大腦皮質切片 酸素消費量 및 Na^(+), K^(+) 消長에 미치는 影響

The Effect of Ginseng Saponin on Morphine Action of 빼₂ and Na, K content in Cerebral Cortex Slices of Rat

대한약리학잡지 1969년 5권 1호 p.29 ~ 33
박찬웅 (  ) - 서울대학교 의과대학 약리학교실

Abstract


The effects of Ginseng saponin on respiration and Na^(+), K^(+) content of rat cerebral cortex slices were investigated to determine the action of Ginseng saponin on brain cortex at cellular level.
There are many reports for the study of Ginseng on central stimulatory action in experimental animals.
The electrical stimulation of slices of cortex causes a loss of potassium. And the respiration is needed to maintain a supply of energy for active cation transport.
The reduction in O_(~)o₂ is a consequence of primary cessation of active cation transport. Ginseng saponin stimulated respiration which was depressed by Morphine. But there was no significant change of electrolyte. It is suggested that the Ginseng saponin act rather on metabolic process than neural excitatory mechanism in vitro.

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