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개구리 心房의 Adrenotropic Receptor

Adrenotropic Receptor in the Frog Atria

대한약리학잡지 1969년 5권 1호 p.35 ~ 38
조순임 (  ) - 전남대학교 의과대학 약리학교실

Abstract


1. On isolated atrial preparation of frog, effects of sympathomimetic amines were investigated.
2. Isoproterenol, epinephrine, norepinephrine, and phenylephrine produced positive chronotropic and inotropic effects. The relative potencies for the effects of these agents were: isoproterenol>epinephrine>norepinephrine>phenylephrine. Methoxamine had no effects or depressed the atria.
3. Pronethalol antagonized the positive effects of these adrenergic agents competitively.
4. Regitine did not affect the effects of these agents.
5. These data indicate that the adrenergic agents activate the atrial tissue of the frog via stimulation of adrenergic beta-receptor.

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