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Diphenylhydantoin 및 數種의 中樞神經系에 作用하는 藥物이 흰쥐 大腦皮質切片의 酸素消費量 및 non-inulin space Na^(+), K^(+)濃度에 미치는 影響

The Effects of Diphenylhydantoin and Several other Agents Acting on CNS on the QO₂ and Non-inulin Space Na^(+), K^(+) Concentration in Cerebral cortcial Slices of Rat

대한약리학잡지 1969년 5권 2호 p.13 ~ 18
馬天一 (  ) - 서울대학교 의과대학 약리학교실

林定圭 (  ) - 서울대학교 의과대학 약리학교실
곽형우 (  ) - 서울대학교 의과대학 약리학교실

Abstract


The effects of dephenylhydantoin, strychnine, coramine, d-amphetamine and chlorpromazine on ??O₂ and non-inulin space Na^(+), K^(+) concentration of rat cerebral cortical slices incubated in pH 7.4 glycylglycine glucose saline was investigated.
In general, there are decreased non-inulin space Na^(+) concentration or increased non-inulin space K^(+) concentration or both when the ratio of respiration to non-inulin space is greater than control group except in case of chlorpromazine 10^(-4) M. And it is suggested that the ratio of respiration to non-inulin space is responsible more closely for the non-inulin space Na, K concentration than ??O₂ expressed per tissue wet weight.
Effects of diphenylhydantoin and several other agents on electrolytes and the electroshock seizure threshold are discussed.

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