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人蔘 各 Fraction이 Nembutal, Chlorpromazine 및 Reserpine 投與로 因한 Mouse體溫下降에 미치는 影響

Influence of Each Fraction from Panax Ginseng on the Hypothermia in Mice Elicited by Reserpine;Nembutal and Chlorpromazine

대한약리학잡지 1969년 5권 2호 p.19 ~ 29
洪思岳 (  ) - 서울大學校 醫科大學 藥理學敎室

趙恒英 (  ) - 서울大學校 醫科大學 藥理學敎室
洪淳根 (  ) - 中央專賣技術硏究所

Abstract


Saponin, essential oil, fat oil and alkaloidal fraction were fractionated from the ethanol extract of Panax ginseng.
Effect of each fraction of Panax ginseng upon the temperature response induced by reserpine, chlorpromazine and nembutal was investigated in mice, so as to secure some hidden facets of each fraction of Panax ginseng acting upon central nervous system.
The authors could arrive at some results, that is:
(1) Inhibitory effect of Panax ginseng upon temperature decline induced by nembutal and chlorpromazine and potentiating action upon hyperthermia induced by reserpine reside mainly in saponin fraction and slightly in essential oil fraction.
(2) The effect of Ginseng saponin on temperature response in mice seems to be related with the liberation of serotonin and histamine.

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