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감초 알카로이드에 관한 연구(제4보)

Studies on Alkaloid of Glycyrrhiza glabra L. Ⅳ

대한약리학잡지 1969년 5권 2호 p.75 ~ 78
김석환 (  ) - 서울대학교 의과대학 약리학교실

李權鎬 (  ) - 서울대학교 의과대학 약리학교실
조항영 (  ) - 서울대학교 의과대학 약리학교실
이철우 (  ) - 서울대학교 의과대학 약리학교실

Abstract


Anti-ulcer activity of licorice alkaloid fraction, separated from Glycyrrhiza glabra L. by fractionation according to general alkaloid purification procedure, were studied with various experimental gastric ulcers.
In Shay ulcer, licorice alkaloid fraction inhibit significantly response rate and severity of ulcer. But there was no significant changes in volume and pH of gastric contents.
A male rat was fixed on a board and immersed up to breast in water of 25℃ for 20 hrs. Hemorrhage and erosion developed in all the animals on the mucosa of the glandular portion of stomach.
Licorice alkaloid fraction (5 mg/kg, 10 mg/kg) inhibit significantly in the severity of stress ulcer but there was no changes in the response rate.
Chlorpromazine produce marked inhibition in the severity and response rate of ulcer.
It was suggested that at least the anti-ulcer activity of licorice alkaloid fraction was not mediated by central depression.

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