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망상어 剔出子宮에 對한 自律神經劑의 作用

Actions of Autonomic Drugs on the Uterine Muscle of Ditrema Temmincki Bleeker

대한약리학잡지 1970년 6권 1호 p.37 ~ 44
조정식 (  ) - 부산대학교 의과대학 약리학교실

Abstract


The author studied the actions of autonomic drugs on the uterine muscle isolated from Ditrema temmincki Bleeker, and the results obtained were summerized as follows.
1) The motility of the fish uterus was stimulated by epinephrine, norepinephrine and phenylephrine, but inhibited by isoproterenol.
2) The inhibitory effects of isoproterenol on the fish uterus was not affected by pbenoxybenzamine, but blocked by propranolol.
3) The excitatory effects of phenylephrine on the fish uterus were blocked by pbenoxybenzamine, but stimulated by propranolol.
4) The excitatory effects of epinephrine and norepinephrine were reversed by phenoxybenzamine and stimulated by propranolol.
5) The motility of the fish uterus pretreated with phenoxybenzamine and propranolol was not affected by isoproterenol, phenylephrine, epinephrine and norepinephrine.
6) It seemed that the uterine muscle of the fish had both alpha excitatory and beta inhibitory receptors.
7) The motility of the uterus of the fish was stimulated by acetylcholine. The stimulating action of acetylcholine was antagonized by atropine.
8) The motility of fish uterus was not affected by nicotine and DMPP. The actions of these drugs were not affected by pretreatment with hexamethonium and atropine.
9) It is, therefore, concluded that there are not present ganglia cells furnished with cholinergic fiber in the uterine wall of the fish.

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