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인삼의 중추신경계에 대한 작용

Efffects of Panax Ginseng on the Central Nervous System

대한약리학잡지 1970년 6권 2호 p.11 ~ 19
洪思岳 (  ) - 서울대학교 의과대학 약리학교실

吳鎭燮 (  ) - 서울대학교 의과대학 약리학교실
朴贊雄 (  ) - 서울대학교 의과대학 약리학교실
張鉉甲 (  ) - 서울대학교 의과대학 약리학교실
金應贊 (  ) - 서울대학교 의과대학 약리학교실

Abstract


The effects of Panax Ginseng upon the conditioned avoidance response (CAR) in rats were studied.
In the acquisition experiment, 20 albino rats were fed 2 mg/kg Ginseng ethanol extract, 8 rats were fed 10 mg/kg Ginseng ethanol extract, mixed with daily food, and 39 rats were treated with placebo as control.
Training of avoidance conditioning was done in a two-way shuttle box which was separated into two compartments by a guilotine door. The conditioned stimulus (CS) was a light beam and the unconditioned stimulus (US) was an electric shock, 40-60 volt a.c., to the feet. The shock was presented 3 sec, after onset of the CS and continued until the animal crossed to the opposite safety compartment. Each subject was received 15 trials a day (one session) for 12 consecutive sessions. The number of CR which avoided successfuly without having shock was servrd as an index of learning performance.
An attempt to evaluate gross changes in general emotional reactivity with Ginseng treated rats, a four point rating scale method by Brady and Nauta was adopted. Ratings were made for all animals on the following behavior components, 1) resistance to capture in home cage, 2) resistance to capture from shuttle box, 3) numbert of fecal balls during CAR.
In the Exinction situation, animals who showed above 80 trials of successful CR among total of 180 acquisition trials were chosen as the subject. Eight rats from 2 mg/kg-Ginseng group and 10 normal placebo rats were tested. The experimental procedure was just same as the acquisition test except they have no shock in any case. Fifteen trials a day for 10 consecutive days were done.
The results were as follows,
1) In the acquisition of CAR, 2 mg/kg-Ginseng group showed significantly more CR than normal placebo group in total avoidance trials (table 1, fig 1), but 10 mg/kg-Ginseng group did not differ significantly from normal placebo but tended to be slightly increased CR than that of control did.
2) In the extinction of CAR, 2 mg/kg-Ginseng animals were not differed significantly from normal controls but the decremental extinction tendency was slightly delayed in 2 mg/kg-Ginseng than in normal placebo (table 2, fig 2).
3) The aggressive reactivity of the Ginseng treated group was significantly greater than that of the control group in capture from home cage, but not differed in capture from the shuttle bex. The Ginseng treated animals defecated significantly less frequent than the placebo control during the CAR (table 3,4,5, fig. 3,4,5)).
4) These results suggest that the Ginseng extract may have a stimulant action on the central nervous system.

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