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家兎骨格筋 phosphorylase 活性度에 對한 交感神經效能劑 및 封鎖劑의 作用

Efffects of Adrenergic Agents and Adrenergic Blocking Agents on the Phosphorylase Activity of Rabbit Skeletal Muscle

대한약리학잡지 1970년 6권 2호 p.21 ~ 30
孫龍錫 (  ) - 釜山大學校 醫科大學 藥理學敎室

朴重陽 (  ) - 釜山大學校 醫科大學 藥理學敎室
崔信貞 (  ) - 釜山大學校 醫科大學 藥理學敎室

Abstract


The phosphorylase activation after adrenergic agents administration and the relative abilities of several adrenergic blocking agents to block adrenergic agents induced phosphorylase activation in skeletal muscle was studied in rabbits. The results were as follows.
1) The phosphorylase activity of skeletal muscle was activated by the adrenergic agent such as epinephrine, norepinephrine, isoproterenol and quinterenol.
2) The phosphorylase activity was slightly stimulated by adrenergic alpha-receptor blocking agent such as phentolamine and phenoxybenzamine, but slightly inhibited by adrenergic beta-receptor blocking agents such as DCI, Pronethalol and Propranolol.
3) Skeletal phosphorylase activation by adrenergic agents was blocked by the administration of adrenergic beta-blocking agents such as Propranolol, but not blocked by adrenergic alpha-blocking agents such as Phentolamine and Phenoxybenzamine.

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