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Skin Radioprotector (Diethone) Modifying Dermal Response of Radiation on Rats

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È«¼º¾ð ( Hong Seong-Eon ) - °æÈñ´ëÇб³ Àǰú´ëÇÐ Ä¡·á¹æ»ç¼±°úÇб³½Ç

 ( Urahashi Singo ) - ÀϺ»´ëÇÐ ÀÇÇкΠ¹æ»ç¼±°úÇб³½Ç
 ( Kamata Rikisaburo ) - ÀϺ»´ëÇÐ ÀÇÇкΠ¹æ»ç¼±°úÇб³½Ç

Abstract

DiethoneÀÇ ÇǺο¡ ´ëÇÑ ¹æ»ç¼± º¸È£ÀÛ¿ëÀ» Æò°¡Çϱâ À§ÇÏ¿© Wistar°è ·§µå¿¡ ´ÜÀÏ X-°Ç(20, 30, 40 Gy) Á¶»ç ÈÄ ½Ã°£°æ°ú¿Í ¼±·®º¯È­¿¡ µû¸¥ ±Þ¼º ÇǺιÝÀÀÀ» ¿¬±¸ÇÏ¿´´Ù. 40 Gy ¼±·®¿¡¼­ Diethone±ºÀÇ ÇǺιÝÀÀ±â°£Àº 24.7ÀÏ·Î ´ëÁ¶±º(29.8ÀÏ)°ú ¹Ù¼¿¸°(29.2ÀÏ) Åõ¿©±º¿¡ ºñÇÏ¿© ¾à 17%ÀÇ ÇǺιÝÀÀ ±â°£ÀÌ ¶Ñ·ÇÀÌ °¨¼Ò µÇ¾ú´Ù. ÇǺιÝÀÀÀÌ ÃÖ°íµµ¿¡ ´ÞÇÑ 10ÀÏ µ¿¾ÈÀÇ Æò±ÕÄ¡´Â Diethone±º(2.43)ÀÌ ´ëÁ¶±º(2.91)°ú ¹Ù¼¿¸°(2.81)±º¿¡ ºñÇÏ¿© ÇöÀúÈ÷ °¨¼ÒµÇ¾ú´Ù. ÇǺιÝÀÀ Score 2.5¿¡¼­ ±¸ÇÑ µî°¡È¿°ú ¼±·®ÀÇ ¹ÝÀÀ°¨¼Ò °è¼ö(DRF)´Â 1.41·Î ÇǺκ¸È£È¿°ú°¡ ÀÖ¾ú´Ù.
º» ½ÇÇè °á°ú·Î º¸¾Æ ¹æ»ç¼± ÇǺκ¸È£Á¦¸¦ ±¹¼ÒÀûÀ¸·Î µµÆ÷ÇÔÀ¸·Î½á ÀϹÝÀûÀÎ Ä¡·á¼±·®º¸´Ù ¸¹Àº ¹æ»ç¼±·®À» °Å´ëÇÏ°í ¹æ»ç¼±³»¼ºÀÌ ÀÖ´Â Á¾¾ç¿¡ Á¶»çÇÔÀ¸·Î½á Ä¡·áÈ¿°ú¸¦ Çâ»ó½Ãų ¼ö ÀÖÀ» °ÍÀ¸·Î ±â´ëÇÑ´Ù.

Investigations were carried out into the time-and dose-related changes in acute skin reaction following graded single dose (20, 30 and 40 Gy) of x-ray irradiation in Wistar rats, in order to evaluate the radioprotective effect of Diethon on skin. For the duration of skin response over 1. 5 score in dose of 40 Gy, the Diethone group of 24.7 days was significantly different (p<0.02) from that of control (29.8 days) and vaseline (29.2 days) groups, it was 17.1% diminution of skin response period compared with that of control group. By the averaging daily scores for 10 days during peak skin reaction the mean scores were obtained. Mean score of Diethone group (2.43¡¾0.22) was significantly different (p<0.01) from that of control (2.91¡¾0.23) and vaseline (2.81¡¾0.18) groups of 40 Gy dose. By iso-effect dose obtained at level of 2.5 score the dose reduction factor(DRF) was 1.41 which reduced radiation dose of 41% by radioprotective effect of Diethone.
From this experimental data, it may be possible to give higher radiation dose to large and/or radioresistant tumor mass rather than conventional treatment doses for improving therapeutic ratio by using topical application of skin radioprotector.

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Diethone;Skin Reaction;X-ray;Radioprotective effect
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