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Cronkhite-Canada 증후군 환자 1예에서 발생한 미만성탈모증의 임상, 병리적 특징

Clinco-pathologic Features of Alopecia in a Patient of Cronkhite-Canada Syndrome

대한피부과학회지 2019년 57권 7호 p.391 ~ 394
성기현 ( Seong Gi-Hyun ) - 단국대학교 의과대학 피부과학교실

손우리 (  ) - 단국대학교 의과대학 피부과학교실
박명진 (  ) - 단국대학교 의과대학 피부과학교실
박민기 ( Park Min-Kee ) - 단국대학교 의과대학 피부과학교실
홍승필 ( Hong Seung-Phil ) - 단국대학교 의과대학 피부과학교실
김명화 ( Kim Myung-Hwa ) - 단국대학교 의과대학 피부과학교실
박병철 ( Park Byung-Cheol ) - 단국대학교 의과대학 피부과학교실


Although hair loss in Cronkhite-Canada syndrome (CCS) developed frequently, its exact mechanism has not been elucidated. Thus, we attempted to investigate the histopathologic features of hair loss with scalp biopsy in one case of CSS. The patient complained of persistent diarrhea and diffuse hair loss of the scalp 1 month prior to the hospital visit. CCS has been already diagnosed through colonoscopy and medical examination. Scalp biopsy was performed to evaluate hair loss of the patient, and pathologic examination showed increased telogen hairs (anagen to telogen is 7:8) without specific dermal inflammation and miniaturization of hair follicles. The patient was treated with topical and systemic steroids, and hair loss has almost completely recovered in 5 months. In this case, we investigated the clinical and pathological features of hair loss through scalp biopsy in one case of CCS and reported them with a review of the literature.


Abdominal discomfort; Cronkhite-Canada syndrome; Diffuse alopecia; Ectodermal changes
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