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비분절형 백반증 환자의 노출부위 탈색소반에서 발생한 다발성 광선각화증

Multiple Actinic Keratoses within Vitiliginous Patches in a Patient with Non-segmental Vitiligo

대한피부과학회지 2020년 58권 1호 p.39 ~ 42
신재용 ( Shin Jae-Yong ) - 연세대학교 의과대학 피부과학교실

김도영 ( Kim Do-Young ) - 연세대학교 의과대학 피부과학교실
박수진 ( Park Su-Jin ) - 연세대학교 의과대학 피부과학교실
구자승 ( Koo Ja-Seung ) - 연세대학교 의과대학 병리학교실
한승경 ( Han Seung-Kyung ) - 우태하 한승경 피부과
오상호 ( Oh Sang-Ho ) - 연세대학교 의과대학 피부과학교실

Abstract


A 74-year-old man visited our department with complaints of multiple asymptomatic erythematous scaly crusted patches on the scalp. He had non-segmental vitiligo with the extent of over 20% of the body surface area for 30 years. Biopsies showed hyperkeratosis, foci of atypical, pleomorphic keratinocytes along the basal cell layer, and marked solar elastosis, consistent with actinic keratosis (AK). Melan-A and Fontana-Masson staining showed absence of melanin and melanocytes. Despite conflicting data on the prevalence of skin cancers in patients with vitiligo, it is known that vitiligo does not increase nor decrease the risk of skin cancer. Recent studies have reported that patients with vitiligo lesions show increased epidermal expression of wild-type p53 protein than healthy controls.
However, a few cases of skin cancer have been reported in patients with vitiligo. Here, we report a case of AK developing in vitiligo lesions. Dermatologists should not overlook the possible occurrence of AK or skin cancers in sun-exposed vitiliginous skin.

키워드

Actinic keratosis; Skin cancer; Vitiligo; UV
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