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사자모양 얼굴을 보인 Sezary 증후군

Sezary Syndrome with a Leonine Face

대한피부과학회지 2020년 58권 1호 p.43 ~ 46
조미연 ( Cho Mi-Yeon ) - 강남세브란스병원 피부과

김수찬 ( Kim Soo-Chan ) - 강남세브란스병원 피부과

Abstract


Sezary syndrome is an aggressive, leukemic cutaneous T-cell lymphoma variant, characterized by a triad of circulating neoplastic T cells and erythroderma with/without associated lymphadenopathy. A 51-year-old man presented with erythroderma and multiple nodular skin lesions over the face. The facial skin was thickened, producing “leonine facial” appearance. On physical examination, the axillary and inguinal lymph nodes were enlarged. Investigations revealed the presence of atypical lymphoid cells in the peripheral blood, bone marrow, and skin. The histopathology of skin showed dermal infiltration of atypical small lymphocytes with mild epidermotropism. Immunohistochemical studies showed that the infiltrated cells were positive for CD3 and CD4, but negative for CD8 and CD20. A diagnosis of Sezary syndrome was made based on the clinical, peripheral blood, and immunophenotypical findings.

키워드

Erythroderma; Leonine face; Sezary syndrome
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