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염증성장질환 환자에서의 장관 외 피부 증상: 설문조사 연구 및 문헌 고찰

Extraintestinal Cutaneous Manifestations in Inflammatory Bowel Disease: Survey and Literature Review

대한피부과학회지 2020년 58권 2호 p.77 ~ 85
이승민 ( Lee Seung-Min ) - 순천향대학교 서울병원 피부과

이성열 ( Lee Sung-Yul ) - 순천향대학교 천안병원 피부과
이종석 ( Lee Jong-Suk ) - 순천향대학교 천안병원 피부과
조문균 ( Cho Moon-Kyun ) - 순천향대학교 서울병원 피부과
이상훈 ( Lee Sang-Hoon ) - 순천향대학교 부천병원 피부과
정윤호 ( Jung Yun-Ho ) - 순천향대학교 천안병원 소화기내과
김정은 ( Kim Jung-Eun ) - 순천향대학교 천안병원 피부과

Abstract


Background: Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory disease of the gastrointestinal tract. IBD tends to coincide with several cutaneous symptoms and signs; previous studies have suggested a link between IBD and immune-mediated skin diseases (ISDs) such as psoriasis, rosacea, and atopic dermatitis. However, there is a paucity of reports on extraintestinal cutaneous manifestations in patients with IBD from Asia and Korea.

Objective: We examined the prevalence of cutaneous manifestations in IBD patients and investigated the possible association between IBD and various dermatoses in a Korean tertiary care hospital.

Methods: Detailed questionnaires were administered to 120 patients diagnosed with IBD treated at the gastrointestinal center of our hospital. We also extracted their medical records retrospectively to obtain additional information about both their cutaneous manifestations and IBD, including disease duration and treatment course. A literature review on the prevalence of psoriasis in IBD patients was performed to clarify the association between those diseases.

Results: Crohn’s disease and ulcerative colitis were noted in 58 and 62 cases, respectively. Reactive skin lesions including aphthous stomatitis, erythema nodosum, and pyoderma gangrenosum were found in 12 cases (10%). ISDs such as psoriasis, rosacea, and atopic dermatitis were present in 3.3%, 21.7%, and 12.5% of cases, respectively.
Other dermatoses including herpes zoster, xerosis, and skin fungal infection were also detected.

Conclusion: The prevalence of cutaneous manifestations in IBD is similar to that reported previously in Asian patients. Future investigations on the associations between skin diseases and IBD are needed to understand the pathogenesis and immunologic background of their comorbidities.

키워드

Colitis ulcerative; Crohn disease; Inflammatory bowel diseases; Inflammatory skin diseases
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