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천식환자 허실변증과 객담 cytokine 및 특성 비교분석

A Comparative Analysis of Deficiency-Excess Pattern Identification with Sputum Cytokines and the Characteristics of Asthma Patients

대한한방내과학회지 2019년 40권 4호 p.582 ~ 596
도하윤 ( Do Ha-Yoon ) - 경희대학교 대학원 임상한의학과

유창환 ( Yu Chang-Hwan ) - 경희대학교 대학원 임상한의학과
강성우 ( Kang Sung-Woo ) - 경희대학교 대학원 임상한의학과
김관일 ( Kim Kwan-Il ) - 경희대학교 대학원 임상한의학과
이범준 ( Lee Beom-Joon ) - 경희대학교 대학원 임상한의학과
정희재 ( Jeong Hee-Jae ) - 경희대학교 대학원 임상한의학과


Objective: The aims of this study were to analyze the deficiency-excess pattern identification (虛實辨證) and compare it to the sputum cytokines of asthma patients.

Method: 50 asthma patients who met the inclusion and exclusion criteria were included in this study. They were divided into two groups: deficiency and excess syndrome groups. Sputum examinations were performed including TNF-α, Interleukin (IL)-4, IL-5, IL-10, and IL-13. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), the Visual Analog Scale(VAS), and heart rate variability (HRV) were also measured. We also conducted laboratory tests, including the hematological indexes.

Results: Based on the pattern identification, 50 asthma patients can be divided into two categories of groups: the deficiency syndrome group (N=24) and the excess syndrome group (N=26). In the analysis of sputum cytokines, although the TNF-α, IL-4 and IL-13 were at a higher level in the deficient pattern group than in the excess pattern group, it was insignificantly different. There was a negative correlation in the analysis of QLQAKA and VAS. In the analysis of HRV, although the mean value of VLF, LF, and HF in the deficiency syndrome group was higher than in the excess syndrome group, it was insignificantly different. There was no significant difference in the hematological tests between the deficiency and the excess syndrome group. The mean value of the IgE in the blood tests was five times greater than the reference value.

Conclusion: The cytokines of sputum including TNF-α, IL-4, IL-5, IL-10, and IL-13 were indifferent statistically. Reinforcing the healthy and eliminating the pathogenic factors should be considered.


asthma; pattern identification; deficiency-excess syndrome; sputum; cytokine; QLQAKA; heart rate variability (HRV); IgE
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