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Pembrolizumab 면역치료를 시행 중인 비소세포성 폐암환자의 한방치료 증례보고

Traditional Korean Medicine for Non-Small Cell Lung Cancer Patient Undergoing Pembrolizumab Immunotherapy: A Case Report

대한한방내과학회지 2019년 40권 4호 p.709 ~ 722
심소현 ( Shim So-Hyun ) - 부산대학교 한방병원 내과학교실

서희정 ( Seo Hee-Jeong ) - 부산대학교 한방병원 내과학교실
서형범 ( Seo Hyung-Bum ) - 부산대학교 한방병원 내과학교실
조임학 ( Cho Im-hak ) - 부산대학교 한방병원 내과학교실
이찬 ( Lee Chan ) - 부산대학교 한방병원 내과학교실
김소연 ( Kim So-Yeon ) - 부산대학교 한방병원 내과학교실
한창우 ( Han Chang-Woo ) - 부산대학교 한방병원 내과학교실
박성하 ( Park Seong-Ha ) - 부산대학교 한방병원 내과학교실
윤영주 ( Yun Young-Ju ) - 부산대학교 한방병원 내과학교실
이인 ( Lee In ) - 부산대학교 한방병원 내과학교실
권정남 ( Kwon Jung-Nam ) - 부산대학교 한방병원 내과학교실
홍진우 ( Hong Jin-Woo ) - 부산대학교 한방병원 내과학교실
최준용 ( Choi Jun-Yong ) - 부산대학교 한방병원 내과학교실

Abstract


Objective: The purpose of this study was to report the effect of traditional Korean medicine (TKM) in alleviating the side effects of lung cancer patient undergoing immunotherapy.

Method: A 43-year-old man, who was diagnosed with non-small cell lung cancer, received pembrolizumab treatments. The patient was treated with acupuncture and herbal medicine (Geoeoyangpye-tang) to control various uncomfortable symptoms. The degree of pain was measured by the numeric rating scale (NRS). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30) and the EORTC 13-item lung cancer-specific module (EORTC LC-13 questionnaire) were used to assess the change in the quality of life.

Results: After the TKM treatment, the flank pain and arthralgia based on the NRS were significantly improved. Various uncomfortable symptoms such as fatigue, dyspnea, insomnia, and loss of appetite were also significantly improved, based on the EORTC QLQ-C30 and EORTC QLQ-LC13. The size of the primary tumor was decreased during treatment. The disease status was stable radiologically after two months from discharge.

키워드

non-small cell lung carcinoma; immune checkpoint inhibitor; PD-1 inhibitor; pembrolizumab; traditional Korean medicine; case report
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