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A Retrospective Study on the Effect of Daeshiho-tang on the Lipid Profile in Patients with Uncontrolled Dyslipidemia by Statin

대한한방내과학회지 2019년 40권 6호 p.1026 ~ 1034
노지원 ( Noh Ji-Won ) - 경희대학교 대학원 임상한의과학과

정수민 ( Jeong Su-Min ) - 경희대학교 대학원 임상한의학과
김동현 ( Kim Dong-Hyun ) - 경희대학교 대학원 임상한의학과
유정화 ( Yoo Jung-Hwa ) - 경희대학교 한의과대학 부속한방병원 신장내분비내과
안영민 ( Ahn Young-Min ) - 경희대학교 한의과대학 부속한방병원 신장내분비내과
안세영 ( Ahn Se-Young ) - 경희대학교 한의과대학 부속한방병원 신장내분비내과
이병철 ( Lee Byung-Cheol ) - 경희대학교 한의과대학 부속한방병원 신장내분비내과

Abstract


Objective: This study was conducted to investigate the lipid-lowering effect and safety of Daeshiho-tang in patients with uncontrolled lipid levels by statins.

Methods: We investigated patients who had an abnormal lipid profile even when taking statins and who were administered Daeshiho-tang at Kyung-Hee University Korean Medical Hospital for at least one day between January 2008 and December 2018. Their basal characteristics and examinations were reviewed retrospectively with respect to lipid profile, AST, ALT, GGT, BUN, and creatinine. The lipid profile was composed of total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol. Subgroup analysis was performed on each component of dyslipidemia.

Results: Among 20 participants, there were 10 males and 10 females. The mean BMI was 23.52. Eighty five percent of the participants were diagnosed as having cerebral infarction. After the administration of Daeshiho-tang, total cholesterol and LDL cholesterol were significantly reduced, to 41.3 mg/dl and 33.95 mg/dl, respectively. In subgroup analyses, total cholesterol and LDL cholesterol were significantly decreased, to 63 mg/dl and 54.6 mg/dl, respectively. Liver and kidney function showed no significant difference after taking Daeshiho-tang.

Conclusions: Daeshiho-tang as a decoction or powder had significant lipid-lowering effects on total cholesterol and LDL cholesterol in patients with dyslipidemia. The lipid-lowering effect on total and LDL cholesterol increased in patients with hypercholesterolemia and hyper-LDL-cholesterolemia, respectively. Based on the minimal changes in the liver and kidney function test, Daeshiho-tang would be safe enough to be used in clinics.

키워드

Daeshiho-tang; dyslipidemia; total cholesterol; LDL cholesterol; statin
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