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3주된 생쥐에서 궤양성 대장염 유발을 통한 폐-대장-피부의 상관관계 연구

Study of The Correlation of Lung-Large intestine-Skin by Ulcerative Colitis-Induced 3 Weeks Old Mice

대한한방소아과학회지 2019년 33권 3호 p.103 ~ 111
안상현 ( Ahn Sang-Hyun ) - 세명대학교 한의과대학 해부학교실

김기봉 ( Kim Ki-Bong ) - 부산대학교 한의학전문대학원 한방소아과학교실

Abstract


Objectives: The purpose of this study is to understand the correlations between lung, large intestine, and skin of 3-week-old mice in which ulcerative colitis was induced, up on administration of Coptidis rhizome and Glycyrrhiza uralensis mixed extract.

Methods: Mice were divided into 4 groups as follows; no treatment group (Ctrl group), ulcerative colitis-induced mice group (UE group), ulcerative colitis-induced mice group after administering Pentasa (PT group), ulcerative colitis-induced mice group after administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract (CGT group). Mice were induced ulcerative colitis by Dextran sulfate sodium (DSS). After 5 days of administration, We obvserved anti-inflammatory effect, alveolar formation, and skin barrier control in the colon mucosa.

Results: The CGT group was observed arrangement of normal intestinal cells, Infiltration of less inflammatory cells. The CGT significantly decreased positive rseponse of TNF-α, p-IkB, Caspase 3 in large intestine, and significantly increased positive rseponse of EGF, IGF, catalase, Filaggrin, involucrin, loricrin.

Conclusions: The results of this study show the correlation of Lung-Large intestine-Skin by administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract to ulcerative colitis-induced mice.

키워드

Coptidis rhizoma; Glycyrrhiza uralensis; Ulcerative colitis; Lung; Large intestine; Skin
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