medric medric
잠시만 기다려 주세요. 로딩중입니다.

모유수유와 분유수유에 따른 영아 장내 미생물 군집의 특징

Comparison of gut microbial diversity of breast-fed and formula-fed infants

미생물학회지 2019년 55권 3호 p.268 ~ 273
김경순 ( Kim Kyeong-Soon ) - 한국의과학연구원

신정 ( Shin Jung ) - 한국의과학연구원
심지수 ( Sim Ji-Soo ) - 한국의과학연구원
연수지 ( Yeon Su-Ji ) - 한국엔디랩
이평안 ( Lee Pyeong-An ) - 한국엔디랩
정문규 ( Chung Moon-Gyu ) - 한국의과학연구원


The intestinal microbiomes vary according to the factors such environment, age and diet. The purpose of this study was to compare the gut microbial diversity between Korean infants receiving breast-fed milk and formula-fed milk. We analyzed microbial communities in stool samples collected from 80 Korean infants using next generation sequencing. Phylum level analysis revealed that microbial communities in both breast-fed infants group (BIG) was dominated by Actinobacteria (74.22 ± 3.48%). Interestingly, the phylum Actinobacteria was dominant in formula-fed infants group A (FIG-A) at 73.46 ± 4.12%, but the proportions of phylum Actinobacteria were lower in formulafed infants group B and C (FIG-B and FIG-C) at 66.52 ± 5.80% and 68.88 ± 4.33%. The most abundant genus in the BIG, FIG-A, FIG-B, and FIG-C was Bifidobacterium, comprising 73.09 ± 2.31%, 72.25 ± 4.93%, 63.81 ± 6.05%, and 67.42 ± 5.36% of the total bacteria. Furthermore, the dominant bifidobacterial species detected in BIG and FIG-A was Bifidobacterium longum at 68.77 ± 6.07% and 66.85 ± 4.99% of the total bacteria.
In contrast, the proportions of B. longum of FIG-B and FIG-C were 58.94 ± 6.20% and 61.86 ± 5.31% of the total bacteria.
FIG-A showed a community similar to BIG, which may be due to the inclusion of galactooligosaccharide, galactosyllactose, synergy-oligosaccharide, bifidooligo and improvement material of gut microbiota contained in formula-milk. We conclude that 5-Bifidus factor contained in milk powder promotes the growth of Bifidobacterium genus in the intestines.


Bifidobacterium longum; 5-Bifidus factor; breast-fed; formula-fed; next generation sequencing
원문 및 링크아웃 정보
등재저널 정보