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Changes in serum uric acid levels after allogeneic hematologic stem cell transplantation: A retrospective cohort study

대한혈액학회지 2016년 51권 3호 p.200 ~ 203
주상현 ( Joo Sang-Hyun ) - Seoul National University Hospital Department of Internal Medicine

박진균 ( Park Jin-Kyun ) - Seoul National University Hospital Department of Internal Medicine
 ( Lee Eun-Young Emily ) - Seoul National University Hospital Department of Internal Medicine
송영욱 ( Song Yeong-Wook ) - Seoul National University Hospital Department of Internal Medicine
윤성수 ( Yoon Sung-Soo ) - Seoul National University Hospital Department of Internal Medicine

Abstract


Background: Since cell turnover in the hematopoietic system constitutes a major source of uric acid (UA) production, we investigated whether hematopoietic stem cell transplantation (HSCT) is associated with significant changes in serum UA levels in patients with hematological disorders.

Methods: Patients who underwent HSCT at our institution between 2001 and 2012 were retrospectively enrolled. Serum UA levels at 3 months before, 1 week before, and 3 months and 1 year after HSCT were examined.

Results: Complete clinical and laboratory information including data regarding UA levels was available for 93 patients. At baseline, the mean UA level was 4.9±2.1 mg/dL, with an overall prevalence of hyperuricemia of 15% (defined as serum UA>6.8 mg/dL). Mean UA levels tended to be higher in patients with acute myeloid leukemia (4.8±2.0 mg/dL) and non-Hodgkin lymphoma (5.1±2.3 mg/dL) and lower in patients with aplastic anemia (mean, 4.2±1.8 mg/dL). UA levels dropped during myeloablative conditioning, reaching a nadir on the day of HSCT (3.27±1.4 mg/dL). Over the 3 months following HSCT, UA levels rose sharply (5.0±2.1 mg/dL) and remained stable up to 1 year after HSCT (5.5±1.6 mg/dL). UA levels in HSCT recipients at 12 months correlated with those of their respective graft donors (Pearson r=0.406, P=0.001).

Conclusion: HSCT is associated with significant changes in uric acid levels in patients with hematologic disorders.

키워드

Uric acid; Hematopoietic stem cell transplantation; Bone marrow
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