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알코올가상현실치료: 다감각 자극에 대한 알코올 의존 환자의 갈망 및 뇌파 반응

Virtual Reality Alcohol Treatment : Craving and EEG Responding to Multi-Sensory Stimulation in Patient with Alcohol Dependence

신경정신의학 2009년 48권 4호 p.255 ~ 261
한덕현 ( Han Doug-Hyun ) - 중앙대학교 의과대학 정신과학교실

이상훈 ( Lee Sang-Hoon ) - 인천은혜병원 정신과
오세만 ( Oh Se-Man ) - 인천은혜병원 정신과
이영식 ( Lee Young-Sik ) - 중앙대학교 의과대학 정신과학교실

Abstract

본 연구 결과는 알코올 의존 환자의 전두엽은 술마시는 상황에서 정상인에 비해 불안정하게 반응하며, 이것이 술 에 대한 갈망을 증가시키는 것과 관련이 있을 것으로 생각 된다.

Objectives: In our previous report, alcohol dependent patients (ADP) with virtual reality treatment showed a greater decrease in cravings for alcohol and increase in alpha power of the frontal lobe, compared to ADP who underwent general treatment. For the showing different responsibility on alcohol consumption situation between ADP and healthy comparisons, we compared the change in cravings and alpha waves in frontal lobe during virtual reality treatment for alcohol dependence (VRT).

Methods: Thirty seven alcohol-dependent male inpatients diagnosed using DSM-IV, and 25 ageand education-matched healthy adult males were recruited. We measured the changes in cravings and Electroencephalogram (EEG) activity between alcoholic patients and healthy control subjects during VRT.

Results: During the VRT, ADP reported higher craving for alcohol during the high risk situation and lower craving for alcohol during aversive situation, compared to healthy controls. The alpha wave of frontal lobe activity in ADP was decreased while that in healthy subject was increased from relaxation to high risk situation (HRS). In ADP, the changes of EEG {Fp1-A1 (r=-0.48, p=0.04), F7-A1 (r=-0.49, p=0.03), Fp2-A2 (r=-0.46, p<0.05), and F8-A2 (r=-0.54, p=0.02)} in the frontal lobe were negatively correlated with the change of craving for alcohol.

Conclusion: The present study demonstrated that the ready availability and the affinity of alcohol cues in ADP appear to be correlated with decreased function of the frontal lobe.

키워드

가상현실;알코올의존;갈망감;뇌파;전두피질
Virtual reality;Alcohol dependence;Craving;EEG;Frontal cortex
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