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Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules

Toxicological Research 2019년 35권 4호 p.303 ~ 310
 ( Kumagai Yoshito ) - University of Tsukuba Faculty of Medicine Environmental Biology Laboratory

 ( Akiyama Masahiro ) - University of Tsukuba Faculty of Medicine Environmental Biology Laboratory
 ( Unoki Takamitsu ) - National Institute for Minamata Disease Department of Basic Medical Sciences

Abstract


We are exposed to numerous xenobiotic electrophiles on a daily basis through the environment, lifestyle, and dietary habits. Although such reactive species have been associated with detrimental effects, recent accumulated evidence indicates that xenobiotic electrophiles appear to act as signaling molecules. In this review, we introduce our findings on 1) activation of various redox signaling pathways involved in cell proliferation, detoxification/ excretion of electrophiles, quality control of cellular proteins, and cell survival during exposure to xenobiotic electrophiles at low concentrations through covalent modification of thiol groups in sensor proteins, and 2) negative regulation of reactive sulfur species (RSS) in the modulation of redox signaling and toxicity caused by xenobiotic electrophiles.

키워드

Electrophiles; Covalent modification; Redox signaling; Reactive sulfur species
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