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Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin

Toxicological Research 2019년 35권 4호 p.353 ~ 359
 ( Park Kyo-Hyun ) - Keimyung University Department of Public Health

 ( Kim Ji-Yeon ) - Keimyung University Department of Public Health
 ( Jung Su-Ryun ) - Keimyung University Department of Public Health
 ( Sung Kyung-Hwa ) - Daegu Catholic University Environmental Health Services Center
 ( Son Yeon-Kyoung ) - Food & Supplement Health Claims R&D Team
 ( Bae Jung-Min ) - Agency for Korea National Food Cluster
 ( Kim Bae-Hwan ) - Keimyung University Department of Public Health


The purpose of this study was to investigate the effect of 7-MEGATM 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGATM 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGATM 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGATM 500. Therefore, the intake of 7-MEGA TM 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.


7-MEGATM 500; Photoaging; Hairless mice; c-Jun; MMP-3
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