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Toxicological Evaluation of Saposhnikoviae Radix Water Extract and its Antihyperuricemic Potential

Toxicological Research 2019년 35권 4호 p.371 ~ 387
 ( Kim Chang-Won ) - Kyung Hee University Department of Oriental Medicine and Biotechnology

 ( Sung Jae-Hyuck ) - Korea Conformity Laboratories
 ( Kwon Jeong-Eun ) - Kyung Hee University Department of Oriental Medicine and Biotechnology
 ( Ryu Hyeon-Yeol ) - Korea Conformity Laboratories
 ( Song Kyung-Seuk ) - Korea Conformity Laboratories
 ( Lee Jin-Kyu ) - Korea Conformity Laboratories
 ( Lee Sung-Ryul ) - Inje University College of Medicine Department of Integrated Biomedical Science
 ( Kang Se-Chan ) - Kyung Hee University Department of Oriental Medicine and Biotechnology

Abstract


Although the dried root of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a popular medicinal plant in East Asia, there has been no systemic toxicological evaluation of a water extract of Saposhnikoviae Radix (SRE). In this experiment, an oral acute and 13-week subchronic toxicological evaluations of SRE (500-5,000 mg/ kg body weight) were performed in both sexes of Crl:CD(SD) rats. Based on the results from mortality, clinical signs, effects on body weight and organ weight, clinical biochemistry, hematology, urinalysis, and histopathology, significant acute, 4-week repeated dose range finding (DRF) and 13-week subchronic toxicity of SRE was not observed in either sex of rats; thus, the no observed adverse effect level (NOAEL) was 5,000 mg (kg/day). To identify anti-hyperuricemia potential of SRE, the suppressive effect of SRE was determined in mice challenged with potassium oxonate (PO; 250 mg/kg) via intraperitoneal injection for 8 days (each group; n = 7). SRE supplementation suppressed the uric acid level in urine through significant xanthine oxidase (XO) inhibitory activity. Kidney dysfunctions were observed in PO-challenged mice as evidenced by an increase in serum creatinine level. Whereas, SRE supplementation suppressed it in a dose-dependent manner. Collectively, SRE was safe up to 5,000 mg (kg/day) based on NOAEL found from acute and 13-week subchronic toxicological evaluations. SRE had anti-hyperuricemia effect and lowered the excessive level of uric acid, a potential factor for gout and kidney failure.

키워드

Saposhnikoviae radix; 13-week repeated toxicity; NOAEL; Potassium oxonate; Anti-hyperuricemia; Extract
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