medric medric
잠시만 기다려 주세요. 로딩중입니다.

Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice

Toxicological Research 2019년 35권 4호 p.403 ~ 410
 ( Yang Jin-Won ) - Woosuk University College of Pharmacy

 ( Yeo Hee-Kyung ) - HANDOK Inc.
 ( Yun Jee-Hye ) - HANDOK Inc.
 ( Lee Jung-Un ) - ChemOn Inc.


Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, including antioxidant, anti-inflammatory, and chemo-preventive activities. Curcumin has been shown to have potential in preventing nonalcoholic fatty liver disease (NAFLD). However, the low bioavailability of curcumin has proven to be a major limiting factor in its clinical adoption. Theracurmin, a highly bioavailable curcumin that utilizes micronized technology showed improved biological absorbability in vivo. The aim of this study was to investigate the role of theracurmin in modulating hepatic lipid metabolism in vivo. A fatty liver mouse model was produced by feeding mice a high fat diet (HFD; 60% fat) for 12 weeks. We found that treatment for 12 weeks with theracurmin significantly lowered plasma triacylglycerol (TG) levels and reduced HFD-induced liver fat accumulation. Theracurmin treatment lowered hepatic TG and total cholesterol (T-CHO) levels in HFD-fed mice compared to controls. In addition, theracurmin administration significantly reduced lipid peroxidation and cellular damage caused by reactive oxygen species in HFD-fed mice. Overall, these results suggest that theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.


Theracurmin; Curcumin; Nonalcoholic fatty liver disease (NAFLD); High fat diet (HFD); Fatty liver; Steatosis
원문 및 링크아웃 정보
등재저널 정보