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Thirteen-week inhalation toxicity study of 1-methylnaphthalene in F344 rats

Toxicological Research 2020년 36권 1호 p.13 ~ 20
김용순 ( Kim Yong-Soon ) - Occupational Safety and Health Research Institute

이미주 ( Lee Mi-Ju ) - Occupational Safety and Health Research Institute
 ( Seo Dong-Suk ) - Occupational Safety and Health Research Institute
 ( Kim Tae-Hyun ) - Occupational Safety and Health Research Institute
 ( Kim Min-Ha ) - Occupational Safety and Health Research Institute
임철홍 ( Lim Cheol-Hong ) - Occupational Safety and Health Research Institute

Abstract


1-Methylnaphthalene is generally utilized in solvents, as an intermediate in organic synthesis, a dye carrier, in resins, and others. There are some toxicological studies of 1-methylnaphthalene; however, inhalation toxicity studies are rare. Each of 10 male and female F344 rats was exposed to vapors of 1-methylnaphthalene for 13 weeks (6 h a day, 5 days per week) at concentrations of 0, 0.5, 4, and 30 ppm in a whole-body inhalation chamber system. The exposure concentrations were 0.52?±?0.05, 4.08?±?0.25, and 30.83?±?1.28 ppm for the low-, middle-, and high-dose group, respectively. Body weight changes were not affected by exposure to 1-methylnaphthalene. Blood prothrombin time was delayed at 30 ppm in male and female groups, and activated partial thromboplastin time was also delayed at 30 ppm in the male group. Values of alanine aminotransferase in the serum were decreased and those of albumin were increased at 30 ppm in the male group. Differential cell counts and levels of lactate dehydrogenase in the bronchoalveolar lavage fluid were not affected. However, mucous cell hyperplasia in the nasopharyngeal tissues was found and the severity was correlated to exposure concentrations. In conclusion, 1-methylnaphthalene mainly affects the upper respiratory system and the no-observed-adverse-effect level is suggested to be 4 ppm on the basis of histopathological findings.

키워드

Inhalation toxicity; 1-Methylnaphthalene; No-observed-adverse-effect level; Upper respiratory system
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