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Momordica charantia mitigates hepatic injury following adjuvant treatment with antiretroviral drugs in diabetic animal models

Toxicological Research 2020년 36권 1호 p.37 ~ 44
 ( Offor Ugochukwu ) - University of Kwazulu-Natal Nelson R. Mandela School of Medicine Discipline of Clinical Anatomy

 ( Naidu Edwin C. S. ) - University of Kwazulu-Natal Nelson R. Mandela School of Medicine Discipline of Clinical Anatomy
 ( Ogedengbe Oluwatosin O. ) - University of Kwazulu-Natal Nelson R. Mandela School of Medicine Discipline of Clinical Anatomy
 ( Aniekan Peter I. ) - University of Kwazulu-Natal Nelson R. Mandela School of Medicine Discipline of Clinical Anatomy
 ( Azu Onyemaechi O. ) - University of Kwazulu-Natal Nelson R. Mandela School of Medicine Discipline of Clinical Anatomy

Abstract


Momordica charantia (M. charantia) is a medicinal plant, used in traditional practice for treating diseases like hypertension and diabetes mellitus. This study investigated the possible hepato-protective effect of M. charantia following treatment with highly active antiretroviral therapy (HAART) in diabetic rats. 48 adult male Sprague Dawley rats were divided into seven groups (A?G) of 7 animals per group and treated according to protocols. Diabetes was induced with streptozotocin (STZ) by intraperitoneal injection (45 mg/kg body weight). The animals were euthanized on the 10th week with liver removed for examination and blood obtained via cardiac puncture and centrifuged to collect the sera. Blood glucose levels (BGL) were consistently and significantly raised (p?

키워드

Highly active antiretroviral therapy; Hepatotoxicity; Liver; Diabetes mellitus; Momordica charantia; Sprague-dawley rats
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