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Action mechanism of anti-wrinkle effect of Rhamnus yoshinoi methanol extract in human dermal fibroblast and keratinocyte cell lines

Toxicological Research 2020년 36권 1호 p.69 ~ 77
 ( Kim Hyun-Ok ) - Keimyung University Graduate School Department of Public Health

 ( Shin Kyoung-Ran ) - Keimyung University School of Medicine Department of Molecular Medicine
 ( Jang Byeong-Churl ) - Keimyung University School of Medicine Department of Molecular Medicine
김용철 ( Kim Young-Chul ) - Keimyung University Graduate School Department of Public Health

Abstract


Rhamnus yoshinoi is a deciduous broad-leaf bush and endemic species widely found in Korea. Recently, we reported that R. yoshinoi methanol extract (RYME) had excellent antioxidant activity and inhibition of collagenase and elastase activity in cell-free system. In this study, we investigated the ability of RYME to control the mRNA and protein expression levels of the known skin wrinkle-related factors in cultured human dermal fibroblast and keratinocyte cell lines. Treatment with 100 or 200 μg/mL RYME strongly blocked the UVB-induced downregulation of type 1 collagen mRNA expression (p?

키워드

Anti-wrinkle effect; CCD-986sk cells; ERK-1/2 protein phosphorylation; HaCaT cells; MMP-3; Rhamnus yoshinoi
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