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Acute and 13-week subchronic toxicity studies of hot-water extract of Cynanchi wilfordii Radix in Sprague-Dawley rats

Toxicological Research 2020년 36권 1호 p.89 ~ 98
 ( Han Chung-Tack ) - Biotoxtech Co.

 ( Kim Du-Yeol ) - Biotoxtech Co. Ltd.
남춘자 ( Nam Chun-Ja ) - Biotoxtech Co. Ltd.
문설희 ( Moon Seol-Hee ) - Biotoxtech Co. Ltd.
박순희 ( Park Sun-Hee ) - Biotoxtech Co. Ltd.
 ( Han Kyoung-Goo ) - Biotoxtech Co. Ltd.
이혜영 ( Lee Hye-Yeong ) - Biotoxtech Co. Ltd.
 ( Bae Heung-Mo ) - Biotoxtech Co. Ltd.
박철범 ( Park Cheol-Beom ) - Biotoxtech Co. Ltd.
소재현 ( So Jai-Hyun ) - National Development Institute of Korean Medicine
 ( Kang Suk-Mo ) - Biotoxtech Co. Ltd.
강종구 ( Kang Jong-Koo ) - Biotoxtech Co. Ltd.

Abstract


Cynanchi wilfordii Radix (CWR) is a herbal medicinal plant that is well-known and used in Asian countries as a health food. In this study, acute and 13-week subchronic oral toxicity studies of hot-water extract of CWR (CWR-WE) were performed in Sprague-Dawley rats. For the acute toxicity study, CWR-WE was administered once orally to five male and five female rats at doses of 800, 2000, and 5000 mg/kg. Mortality, clinical signs, and body weight changes were monitored over 14 days. There were no treatment-related changes in these parameters and the approximate lethal dose of CWR-WE in male and female rats was determined to be?>?5000 mg/kg. For the subchronic toxicity study, CWR-WE was administered orally once daily to male and female rats for 13 consecutive weeks at doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg/day (n?=?10 rats/sex/group). There were no toxicologically significant changes with regard to clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, clinical chemistry, organ weights, necropsy findings, and histopathological findings. These results suggest that the oral no observed adverse-effect level of CWR-WE is?>?2000 mg/kg/day for both sexes, although target organs were not identified.

키워드

Cynanchi Wilfordii radix; Acute oral toxicity; Subchronic oral toxicity
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