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식물생리활성물질과 과일류 추출물이 MCF-7 유방암 세포에서 H2O2 로 유도된 Poly(ADP-ribose) Polymerase (PARP) 활성도에 미치는 영향

Effects of selected phytochemicals and fruit extracts on Poly(ADP-ribose) polymerase (PARP) activity induced by H2O2 in MCF-7 breast cancer cells

한국식품과학회지 2019년 51권 5호 p.499 ~ 502
윤현근 ( Yoon Hyun-Geun ) - 성신여자대학교 바이오식품공학과

Abstract


Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to DNA damage, and which mediates DNA repair. PARP inhibitors can be used to reduce resistance of cancer cells to anticancer treatments. The objective of this study was to investigate the effects of selected phytochemicals and fruit extracts on PARP activation in MCF-7 breast cancer cells subjected to oxidative stress. Pre-incubation with epigallocatechin gallate (EGCG), apple extract (AE), cranberry extract (CE), or grape extract (GE) for 2 hours at test concentrations reduced PARP activity induced upon treatment with hydrogen peroxide in a dose-dependent manner (p<0.05). GE was found to be the most efficient PARP inhibitor among the fruit extracts examined. These results suggest that phytochemicals of fruit extracts might be used as PARP inhibitors in order to assist anticancer agents.

키워드

PARP inhibitor; phytochemical; EGCG; fruit extract
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