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감 심지 에탄올 추출물의 항산화 활성 및 신경세포 보호 효과

Antioxidant activity and neuroprotective effects of ethanol extracts from the core of Diospyros kaki

한국식품과학회지 2020년 52권 1호 p.60 ~ 66
변의백 ( Byun Eui-Baek ) - 한국원자력연구원

김민진 ( Kim Min-Jin ) - 공주대학교 식품공학과
오남순 ( Oh Nam-Soon ) - 공주대학교 식품공학과
박상현 ( Park Sang-Hyun ) - 공주대학교 식품공학과
김우식 ( Kim Woo-Sik ) - 한국원자력연구원
송하연 ( Song Ha-Yeon ) - 한국원자력연구원
한정무 ( Han Jeong-Moo ) - 한국원자력연구원
김광욱 ( Kim Kwang-Wook ) - 공주대학교 식품공학과
변의홍 ( Byun Eui-Hong ) - 공주대학교 식품공학과

Abstract


This study examined the antioxidant activity and neuroprotective effects of ethanol extracts obtained from Diospyros kaki core (DCE). The total polyphenol and flavonoid contents in DCE was 786.47±15.27 and 31.14±0.82 mg/ g, respectively. In addition, DCE exhibited a dose-dependent induction of radical scavenging activity, determined by 1,1- diphenyl-picrylhydrazyl (DPPH), 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonicacid) (ABTS), ferric reducing antioxidant power (FRAP), and reducing power assays. The viability of HT22 hippocampal cells was examined to investigate the neuroprotective effect of DCE. DCE treatment did not induce cytotoxicity at concentrations below 1,000 μg/mL. Additionally, DCE treatment in the background of H2O2 induce oxidative stress revealed a significant increase in the survival rat, indicated by increased SOD activity and decreased levels of MDA, a lipid peroxidation product. Therefore, the results suggest that DCE can be used as a source of natural antioxidants source and a therapeutic agent for the treatment of brain disorders induced by oxidative stress and neuronal damage.

키워드

Diospyros kaki Core; antioxidant activity; neuroprotective effects; neuronal cell
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