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도라지 종자 추출물의 처리가 제2형 당뇨 db/db 마우스의 혈당개선에 미치는 효과

Improvement of blood glucose control in type 2 diabetic db/db mice using Platycodon grandiflorum seed extract

한국식품과학회지 2020년 52권 1호 p.81 ~ 88
김태영 ( Kim Tae-Yeong ) - 국민대학교 식품영양학과

김석중 ( Kim Seok-Joong ) - 동덕여자대학교 식품영양학과
임지영 ( Imm Jee-Young ) - 국민대학교 식품영양학과

Abstract


The biological activities of Platycodon grandiflorum (PG) root extracts have been studied intensively, whereas there are limited number of studies on PG seed extract (PGSE). PGSE was prepared by ethanol extraction, and its antidiabetic effect was evaluated in mice with type 2 diabetes (C57BLKS/J-db/db). Results indicated that the administration of high-dose PGSE (600 mg/kg, wb) significantly stabilized the blood glucose levels, as evidenced by the results of the oral glucose tolerance test. Mice treated with high-dose PGSE exhibited significantly lower serum hemoglobin A1c, insulin, and leptin levels after eight weeks of feeding trial (p<0.05). High-dose PGSE administration significantly improved glucose uptake in the femoral muscle of db/db mice by activating both IRS-1/PI3K/AKT/AS160 and AMPK phosphorylation pathways. GLUT4 translocation from the cytosol to the plasma membrane increased 1.7-fold in the PGSE high-dose group. These results suggest that PGSE has potential for development as an antidiabetic agent.

키워드

Platycodon grandiflorum; seed extract; db/db mice; anti-diabetic effect; cell signaling
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