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A Case Report of Amiodarone-induced Multiple Toxicity after a Long Course of a Low Dose Therapy
À¯µ¿È¯ ( Ryu Dong-Hwan ) - ÇѾç´ëÇб³ Àǰú´ëÇÐ °¡Á¤ÀÇÇб³½Ç
¹ÚÀçÇõ ( Park Jae-Hyeok ) - ÇѾç´ëÇб³ Àǰú´ëÇÐ °¡Á¤ÀÇÇб³½Ç
Ȳȯ½Ä ( Hwang Hwan-Sik ) - ÇѾç´ëÇб³ Àǰú´ëÇÐ °¡Á¤ÀÇÇб³½Ç
¹ÚÈÆ±â ( Park Hoon-Ki ) - ÇѾç´ëÇб³ Àǰú´ëÇÐ °¡Á¤ÀÇÇб³½Ç
Àü¼®Ã¶ ( Jeon Seok-Chol ) - ÇѾç´ëÇб³ Àǰú´ëÇÐ Áø´Ü¹æ»ç¼±°úÇб³½Ç
Abstract
¾Æ¹Ì¿À´Ù·ÐÀº ¿ä¿Àµå¸¦ ÇÔÀ¯Çϰí ÀÖ´Â º¥Á¶Ç»¶õÀÇ À¯µµÃ¼·Î ½É½Ç¼º ºó¸Æ°ú ½É¹æ¼¼µ¿ µî °¢Á¾ ºÎÁ¤¸ÆÀÇ Ä¡·á¿¡ ÀÌ¿ëµÇ°í ÀÖ´Ù. »ó´ç¼öÀÇ ¾Æ¹Ì¿À´Ù·Ð »ç¿ë ȯÀÚ¿¡¼ ´Ù¾çÇÑ ºÎÀÛ¿ëÀÌ ¹ß»ýÇϸç ÀÇ»ç´Â ±× ºÎÀÛ¿ë¿¡ ´ëÇØ Ç×»ó ÁÖÀÇÇÏ¿©¾ß ÇÑ´Ù. 1980³â´ë¿¡ ¿ì¸®³ª¶ó¿¡ µµÀÔµÈ ÀÌÈÄ ¾Æ¹Ì¿À´Ù·ÐÀÇ ºÎÀÛ¿ë¿¡ ´ëÇÑ Áõ·Ê´Â ¸¹ÀÌ º¸°íµÇ¾úÀ¸³ª º» Áõ·Ê¿Í °°ÀÌ Æóµ¶¼º, °©»ó¼±±â´ÉÇ×ÁøÁõ, °¢Á¾ À§Àå°ü°è ºÎÀÛ¿ëÀÌ ÇÑ È¯ÀÚ¿¡¼ ´Ù¹ßÀûÀ¸·Î º¸°íµÈ ¿¹´Â ÈçÇÏÁö ¾Ê´Ù. ÀúÀÚµéÀº ÀÌ·¯ÇÑ ¾Æ¹Ì¿À´Ù·ÐÀÇ ´Ù¹ßÀûÀÎ ºÎÀÛ¿ëÀ¸·Î ½ÉÇÑ Ã¼Áß°¨¼Ò¸¦ °¡Áø Áõ·Ê¸¦ °æÇèÇÏ¿´±â¿¡ ¹®Çå°íÂû°ú ÇÔ²² º¸°íÇÏ´Â ¹ÙÀÌ´Ù.
Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. But it has a wide range of adverse effects, including pulmonary toxicity, thyroid dysfunction, liver toxicity, gastrointestinal events, corneal deposits, peripheral neuropathy and so on. Patients treated with amiodarone should be followed regularly to assess ongoing need for amiodarone, efficacy of the drug, appropriateness of dosage, adverse effects, and potential drug interactions. We experienced a case of severe weight loss due to amiodarone-induced multiple toxicity after a long course of a low dose therapy. So we report this unusual case with literature review. (J Korean Acad Fam Med 2007;28: 460-465)
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amiodarone;adverse effects;pulmonary toxicity;thyrotoxicosis;anorexia;weight loss
KMID :
0384320070280060460
DOI :
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