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만성구속스트레스 동물모델에 대한 JG02의 항우울 효과

Antidepressant Effects of JG02 on Chronic Restraint Stress Animal Model

동의신경정신과학회지 2019년 30권 3호 p.209 ~ 220
유동근 ( You Dong-Keun ) - 대전대학교 한의과대학 한방신경정신과학교실

서영경 ( Seo Young-Kyung ) - 대전대학교 한의과대학 한방신경정신과학교실
이지윤 ( Lee Ji-Yoon ) - 대전대학교 한의과대학 한방신경정신과학교실
김주연 ( Kim Ju-Yeon ) - 대전대학교 한의과대학 한방신경정신과학교실
정진형 ( Jung Jin-Hyeong ) - 대전대학교 천안한방병원 한방신경정신과
최정준 ( Choi Jeong-June ) - 대전대학교 한의과대학 한의생명융합과학교실
정인철 ( Jung In-Chul ) - 대전대학교 한의과대학 한방신경정신과학교실

Abstract


Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine.

Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 ㎎/㎏), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared.

Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus.

Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.

키워드

Depression; Depressive disorder; JG02; Jigyul-tang; Zhiju-tang; FST; OFT; Corticosterone; Serotonin; BDNF
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