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Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects Via Activation of MAPK and STAT3 Pathways

Journal of Microbiology and Biotechnology 2019년 29권 8호 p.1248 ~ 1254
 ( Jeong Min-Ju ) - Seoul National University Department of Agricultural Biotechnology

 ( Kim Jae-Hwan ) - Seoul National University Department of Agricultural Biotechnology
 ( Yang Hee ) - Seoul National University Department of Agricultural Biotechnology
 ( Kang Shin-Dal ) - SPC Group Research Institute of Food and Biotechnology
 ( Song Seong-Bong ) - SPC Group Research Institute of Food and Biotechnology
 ( Lee Deuk-Buhm ) - SPC Group Research Institute of Food and Biotechnology
 ( Lee Ji-Su ) - Incheon National University Division of Bioengineering
 ( Park Jung-Han-Yoon ) - Seoul National University Research Institute of Agriculture and Life Sciences
 ( Byun Sang-Uine ) - Incheon National University Division of Bioengineering
 ( Lee Ki-Won ) - Seoul National University Department of Agricultural Biotechnology

Abstract


Identification of novel probiotic strains is of great interest in the field of functional foods. Specific strains of heat-killed bacteria have been reported to exert immunomodulatory effects. Herein, we investigated the immune-stimulatory function of heat-killed Lactobacillus plantarum KCTC 13314BP (LBP). Treatment with LBP significantly increased the production of TNF-α and IL-6 by macrophages. More importantly, LBP was able to enhance the phagocytic activity of macrophages against bacterial particles. Activation of p38, JNK, ERK, NF-κB, and STAT3 was involved in the immunomodulatory function of LBP. LBP treatment significantly increased production of TNF-α by bone marrow-derived macrophages and splenocytes, further confirming the immunostimulatory effect of LBP in primary immune cells. Interestingly, the immunomodulatory effects of LBP were much stronger than those of Lactobacillus rhamnosus GG, a well-known probiotic strain. These results indicate that LBP can be a promising immune-enhancing functional food agent.

키워드

Lactobacillus plantarum; immunomodulatory effect; phagocytosis; macrophages
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