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Influence of the culture conditions on the production of NGPs by Aspergillus tubingensis

Journal of Microbiology and Biotechnology 2019년 29권 9호 p.1412 ~ 1423
 ( De Leon Lilia Lopez ) - Universite de Toulouse Laboratoire de Genie Chimique

 ( Isaura Caceres ) - Universite de Toulouse Laboratoire de Genie Chimique
 ( Julie Bornot ) - Universite de Toulouse Laboratoire de Genie Chimique
 ( Elodie Choque ) - Universite de Toulouse Laboratoire de Genie Chimique
 ( Jose Raynal ) - Universite de Toulouse Laboratoire de Genie Chimique
 ( Patricia Taillandier ) - Universite de Toulouse Laboratoire de Genie Chimique
 ( Florence Mathieu ) - Universite de Toulouse Laboratoire de Genie Chimique

Abstract


The filamentous fungus Aspergillus tubingensis that belongs to the black Aspergillus section has the capacity to produce high-value metabolites, for instance, Naphtho-Gamma-Pyrones (NGPs). For these fungal secondary metabolites, numerous biological properties of industrial interest have been demonstrated, such as antimicrobial, antioxidant and anti-cancer capacities. It has been observed that these secondary metabolites production is linked with the fungal sporulation. The aim of this research was to apply environmental stresses to trigger the production of NGPs in liquid cultures with CYB (Czapek Dox Broth): osmotic and oxidative stresses. In addition, numerous parameters were tested during the experiments, such as pH value, incubation time, container geometry, and static and agitation conditions. Results demonstrate that the produced amount of NGPs can be enhanced by decreasing the water activity (aw) or by adding an oxidative stress factor. In conclusion, this study can contribute to our knowledge regarding A. tubingensis to present an effective method to increase NGPs’s production, which may support the development of current industrial processes.

키워드

Aspergillus tubingensis; Naphtho-Gamma-Pyrones (NGPs); osmotic stress; oxidative stress
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