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Beyond Viral Interferon Regulatory Factors: Immune Evasion Strategies

Journal of Microbiology and Biotechnology 2019년 29권 12호 p.1873 ~ 1881
명진종 ( Myoung Jin-Jong ) - Jeonbuk National University College of Natural Science Department of Bioactive Material Science

이신애 ( Lee Shin-Ae ) - University of Southern California Keck School of Medicine Department of Molecular Microbiology and Immunology
 ( Lee Hye-Ra ) - Korea University College of Science and Technology Department of Biotechnology and Bioinformatics

Abstract


The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.

키워드

KSHV; viral interferon regulatory factor; immune evasion strategy; PRR-mediated signaling pathway; apoptosis pathway
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