잠시만 기다려 주세요. 로딩중입니다.

Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents

Journal of Microbiology and Biotechnology 2020년 30권 1호 p.1 ~ 10
 ( Jung Jin-A ) - Ewha Womans University Department of Chemistry and Nanoscience

윤여준 ( Yoon Yeo-Joon ) - Ewha Womans University Department of Chemistry and Nanoscience

Abstract


FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure?activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.

키워드

FK506; biosynthesis; antifungal activity; neurotrophic activity
원문 및 링크아웃 정보
등재저널 정보