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Ha-ras Oncogene Inhibits the Mitogenic Stimulation of 12-0-Tetradecanoyl-13-acetate in REF52 Cells and Does Not Affect c-myc Induction

Molecules and Cells 1990년 1권 1호 p.67 ~ 73
 ( Min heung-Shik ) - Seoul National University Department of Microbiology

 ( Kang Hyen-Sam ) - Seoul National University Department of Microbiology

Abstract


Rat cell-line T24REF52 is a non-transformed REF52 clone which expresses T24 Ha-ras oncogene at 10-30% of endogenous protooncogene Ha-ras p21 [Franza et al., (1986) Cell 44, 409-418]. By using T24REF52 cells, it was found that the Ha-ras oncogene inhibits the mitogenic effect of 12-O-tetradecanoyl-13-acetate (TPA). It was not the cytotoxic effect of Ha-ras oncogene, because T24REF52 cells rnitogenically responded to a medium containing 10% fetal calf serum. As c-myc is frequently associated with cell proliferation, the c-myc induction pattern by TPA was observed by RNase hybridization assay. In T24REF52 cells c-myc was induced as normally as in control REF52 cells. Thus Ha-ras oncogene did not affect c-myc expression. We also observed that Ha-ras oncogene did not affect the protein kinase C activity.

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