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Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling

Molecules and Cells 2019년 42권 9호 p.646 ~ 660
 ( Nguyen Quy Thi Cam ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology

 ( Lee Sun-Ji ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Choi Seo-Wha ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Na Yeon-Ju ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Song Mi-Ran ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Hoang Quyen Thi Ngoc ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Sim Seo-Young ) - Daegu Gyeongbuk Institute of Science and Technology Department of New Biology
 ( Kim Min-Sik ) - Daegu Gyeongbuk Institute of Science and Technology Department of New Biology
 ( Kim Jeong-Il ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology
 ( Soh Moon-Soo ) - Sejong University Department of Molecular Biology
 ( Kim Soo-Young ) - Chonnam National University College of Agriculture and Life Sciences Department of Biotechnology

Abstract


Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABAregulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.

키워드

ABI5; abscisic acid; phytohormone; Raf10; signaling; SnRK2s
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