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Lung Cancer Staging and Associated Genetic and Epigenetic Events

Molecules and Cells 2020년 43권 1호 p.1 ~ 9
김도훈 ( Kim Do-Hun ) - Chungbuk National University College of Medicine Department of Thoracic and Cardiovascular Surgery

 ( Lee You-Soub ) - Chungbuk National University College of Medicine Department of Biochemistry
김덕환 ( Kim Duk-Hwan ) - Sungkyunkwan University School of Medicine Department of Molecular Cell Biology
 ( Bae Suk-Chul ) - Chungbuk National University College of Medicine Department of Biochemistry

Abstract


The first step in treating lung cancer is to establish the stage of the disease, which in turn determines the treatment options and prognosis of the patient. Many factors are involved in lung cancer staging, but all involve anatomical information. However, new approaches, mainly those based on the molecular biology of cancer, have recently changed the paradigm for lung cancer treatment and have not yet been incorporated into staging. In a group of patients of the same stage who receive the same treatment, some may experience unexpected recurrence or metastasis, largely because current staging methods do not reflect the findings of molecular biological studies. In this review, we provide a brief summary of the latest research on lung cancer staging and the molecular events associated with carcinogenesis. We hope that this paper will serve as a bridge between clinicians and basic researchers and aid in our understanding of lung cancer.

키워드

adenocarcinoma; epigenetic alteration; lung cancer; mutation; staging
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