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Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity

Molecules and Cells 2020년 43권 1호 p.86 ~ 95
이혜진 ( Lee Hye-Jin ) - Genome Research Foundation Personal Genomics Institute

 ( Kim Jung-Eun ) - Genome Research Foundation Personal Genomics Institute
 ( Weber Jessica A. ) - Harvard Medical School Department of Genetics
 ( Chung Ok-Sung ) - Clinomics Inc.
조윤성 ( Cho Yun-Sung ) - Clinomics Inc.
 ( Jho Sung-Woong ) - Genome Research Foundation Personal Genomics Institute
 ( Jun Je-Hoon ) - Clinomics Inc.
 ( Kim Hak-Min ) - Ulsan National Institute of Science and Technology KOGIC
임정희 ( Lim Jeong-Heui ) - Ministry of Science and ICT National Science Museum
최재필 ( Choi Jae-Pil ) - Genome Research Foundation Personal Genomics Institute
 ( Jeon Sung-Won ) - Ulsan National Institute of Science and Technology KOGIC
 ( Blazyte Asta ) - Ulsan National Institute of Science and Technology KOGIC
 ( Edwards Jeremy S. ) - University of New Mexico UNM Comprehensive Cancer Center
백원기 ( Paek Woon-Kee ) - Ministry of Science and ICT National Science Museum
 ( Bhak Jong ) - Ulsan National Institute of Science and Technology School of Life Sciences Department of Biomedical Engineering

Abstract


The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild. Lifespan in birds is known to be positively correlated with body size and negatively correlated with metabolic rate, though the genetic mechanisms for the red-crowned crane’s long lifespan have not previously been investigated. Using whole genome sequencing and comparative evolutionary analyses against the grey-crowned crane and other avian genomes, including the long-lived common ostrich, we identified red-crowned crane candidate genes with known associations with longevity. Among these are positively selected genes in metabolism and immunity pathways (NDUFA5, NDUFA8, NUDT12, SOD3, CTH, RPA1, PHAX, HNMT, HS2ST1, PPCDC, PSTK CD8B, GP9, IL-9R, and PTPRC). Our analyses provide genetic evidence for low metabolic rate and longevity, accompanied by possible convergent adaptation signatures among distantly related large and long-lived birds. Finally, we identified low genetic diversity in the red-crowned crane, consistent with its listing as an endangered species, and this genome should provide a useful genetic resource for future conservation studies of this rare and iconic species.

키워드

genome; longevity; red-crowned crane
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