잠시만 기다려 주세요. 로딩중입니다.

Role of RUNX Family Transcription Factors in DNA Damage Response

Molecules and Cells 2020년 43권 2호 p.99 ~ 106
 ( Samarakkody Ann Sanoji ) - Harvard Medical School Boston Children’s Hospital Department of Pediatric Hematology-Oncology

 ( Shin Nah-Young ) - Harvard Medical School Boston Children’s Hospital Department of Pediatric Hematology-Oncology
 ( Cantor Alan B. ) - Harvard Medical School Boston Children’s Hospital Department of Pediatric Hematology-Oncology

Abstract


Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi anemia pathways. In this review, we discuss the functional role and mechanisms involved in RUNX factor mediated response to DNA damage and other cellular stresses. We highlight the impact of these new findings on our understanding of cancer predisposition associated with RUNX factor dysregulation and their implications for designing novel approaches to prevent cancer formation in affected individuals.

키워드

cancer; cell cycle arrest; DNA damage response; Fanconi anemia; p53; RUNX1; RUNX2; RUNX3; tumor suppressor
원문 및 링크아웃 정보
 
등재저널 정보