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The Roles of RUNX Family Proteins in Development of Immune Cells

Molecules and Cells 2020년 43권 2호 p.107 ~ 113
 ( Seo Woo-Seok ) - Nagoya University Graduate School of Medicine Department of Immunology

 ( Taniuchi Ichiro ) - RIKEN Center for Integrative Medical Sciences Laboratory for Transcriptional Regulation

Abstract


The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.

키워드

development; immune cells; Runx family; transcription factors
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