잠시만 기다려 주세요. 로딩중입니다.

The Role of RUNX1 in NF1-Related Tumors and Blood Disorders

Molecules and Cells 2020년 43권 2호 p.153 ~ 159
 ( Na You-Jin ) - Cincinnati Children’s Hospital Medical Center Division of Experimental Hematology and Cancer Biology

 ( Huang Gang ) - Cincinnati Children’s Hospital Medical Center Division of Experimental Hematology and Cancer Biology
 ( Wu Jianqiang ) - Cincinnati Children’s Hospital Medical Center Division of Experimental Hematology and Cancer Biology

Abstract


Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder. NF1 patients are predisposed to formation of several type solid tumors as well as to juvenile myelomonocytic leukemia. Loss of NF1 results in dysregulation of MAPK, PI3K and other signaling cascades, to promote cell proliferation and to inhibit cell apoptosis. The RUNX1 gene is associated with stem cell function in many tissues, and plays a key role in the fate of stem cells. Aberrant RUNX1 expression leads to context-dependent tumor development, in which RUNX1 may serve as a tumor suppressor or an oncogene in specific tissue contexts. The co-occurrence of mutation of NF1 and RUNX1 is detected rarely in several cancers and signaling downstream of RAS-MAPK can alter RUNX1 function. Whether aberrant RUNX1 expression contributes to NF1-related tumorigenesis is not fully understood. This review focuses on the role of RUNX1 in NF1-related tumors and blood disorders, and in sporadic cancers.

키워드

cancer; mutation; neurofibromatosis type 1; RUNX1; tumor driver
원문 및 링크아웃 정보
 
등재저널 정보