잠시만 기다려 주세요. 로딩중입니다.

Role of RUNX Family Members in G1 Restriction-Point Regulation

Molecules and Cells 2020년 43권 2호 p.182 ~ 187
 ( Lee Jung-Won ) - Chungbuk National University College of Medicine Department of Biochemistry

 ( Bae Suk-Chul ) - Chungbuk National University College of Medicine Department of Biochemistry

Abstract


When cells are stimulated by growth factors, they make a critical choice in early G1 phase: proceed forward to S phase, remain in G1, or revert to G0 phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G1 will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.

키워드

BRD; PcG complex; restriction point; RUNX; TrxG complex
원문 및 링크아웃 정보
 
등재저널 정보